Wintermute's three difficulty modes "Green Survivor", "Capable Survivor", and "Hardened Survivor" are very similar to Pilgrim, Voyageur, and Stalker difficulties in Survival mode in their AI behavior, predator/prey abundance, and loot tables: however some big distinctions are all player Skills are permanently set to 3 (with skill-ups disabled, so the OP level 5 skill perks cannot be attained), certain 'infinite' duration campfires are present at certain points in the story, and not all crafting recipes available in Survival are available immediately as well (most notably: most animal hide clothing and ammunition crafting being inaccessible).

Currently, indefinite survival is not possible in any of the difficulty modes of Wintermute due to a lack of Beachcombing in all areas. Eventually all ammo/arrows would be consumed, and the only food would be attainable from stoning/snaring rabbits, and even later clothing would deteriorate despite repairs from Cloth shortage. Realistically though due to the abundance of loot (particularly ammunition on lower difficulties) one could comfortably survive for many hundreds of days even with inefficient play on any of these difficulties.